Pau Gasol added 17 points, 11 rebounds and seven assists for San Antonio.
The Spurs improved to 17-2 at home while winning their third straight overall.
The Spurs were without Kawhi Leonard and lost Rudy Gay to a foot injury only two nights after playing with a full roster for the first time all season. Leonard sat out for rest. Gay exited the game late in the third quarter with a sore right heel.
Kyle Anderson had 16 points and eight rebounds starting in place of Leonard. Tony Parker scored 14 points, including 10 in the first quarter as San Antonio bolted to an early lead.
The Spurs led by as many as 17 points in an uncharacteristically high-scoring game for them. San Antonio was limiting opponents to 98 points per game, but New York was able to increase the pace.
San Antonio shot 51 percent from the field while New York shot 46 percent.
Reserve forward Michael Beasley led New York with 23 points. Courtney Lee and Kristaps Porzingis had 18 points apiece, but Porzingis fouled out late in the fourth.
Danny Green was 5 for 8, all on 3-pointers, in adding 15 points for the Spurs.
New York’s Tim Hardaway Jr. missed his 14th straight game with a stress injury to his lower left leg. The Knicks are 5-9 in back-to-back games this season after losing both games for the third time.